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Bronchial provocation determined by breath sounds compared with lung function.

N Noviski1, L Cohen, C Springer

  • 1Department of Paediatrics, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel.

Archives of Disease in Childhood
|August 1, 1991
PubMed
Summary
This summary is machine-generated.

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Bronchial provocation testing using methacholine is safe for children with obstructive lung disease. Listening for wheezing correlates well with objective lung function tests like forced expiratory volume in one second (FEV1).

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Clinical Medicine

Background:

  • Obstructive lung disease, predominantly asthma, affects many children.
  • Accurate assessment of airway hyperresponsiveness is crucial for diagnosis and management.
  • Objective lung function tests can be challenging in young children.

Purpose of the Study:

  • To evaluate the safety and correlation of bronchial provocation testing with methacholine in children aged 5-8 years.
  • To compare wheezing detection over the trachea with objective lung function measurements.

Main Methods:

  • 15 children (5-8 years) with obstructive lung disease underwent methacholine inhalation challenge.
  • Methacholine was inhaled during tidal breathing at increasing concentrations.

Related Experiment Videos

  • Lung function (FEV1) and clinical signs (tracheal wheeze) were assessed independently.

    • Main Results:

    • A close correlation was found between methacholine concentration causing wheezing and that causing a 20% fall in FEV1.
    • Wheezing occurred at a higher methacholine concentration (52% greater on average).
    • The test resulted in a mean FEV1 fall of 33.3% and oxygen saturation drop of 5.2%.

    Conclusions:

    • Bronchial provocation testing using methacholine is a safe method for assessing airway hyperresponsiveness in young children.
    • Clinical assessment of wheezing over the trachea provides a reliable correlate to objective lung function measures.
    • This technique aids in the diagnosis and management of pediatric obstructive lung diseases.