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[Hemostatic disorders in liver disease]

Dana Mitrică1, V L Drug, Cristina Cijevschi Prelipcean

  • 1Universitatea de Medicină Si Farmacie Gr T Popa Iasi, Facultatea de Medicină, Institutul de Gastroenterologie si Hepatologie Iaşi.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
|March 20, 2009
PubMed

Hemorrhagic complications are common in patients with liver diseases and contribute to the morbidity and mortality associated to this condition. The liver plays a central role in the hemostatic process as here all clotting factors and their inhibitors are synthetized. Liver damage is commonly associated with variable impairment of hemostasis due to multiple causes: decreased synthesis of clotting and inhibitor factors, decreased clearance of activated factors, hyperfibrinolysis, accelerated intravascular coagulation, quantitative and qualitative platelet defects. Their clinical implications remain to be elucidated, so further studies addressing this issue are needed.

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