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Updated: Jun 24, 2026

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

Published on: April 4, 2025

[Experimental study regarding the ureteral cicatrization pattern in rabbit].

R A Pintilie¹, Mirela Grigorovici

¹Disciplina de Obstetrică-Ginecologie, Facultatea de Medicină, Universitatea de Medicină si Farmacie "Gr.T. Popa" Iaşi.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi

|March 20, 2009

Summary

This study developed an animal model for ureteral healing after surgical injury. The model shows inflammation and fibrosis, offering insights into urological repair processes.

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Area of Science:

Urology
Surgical Pathology
Animal Models

Context:

Ureteral injuries can occur during surgical procedures.
Effective management requires understanding the wound healing process.
Existing models may not fully replicate human cicatrization timelines.

Purpose:

To establish a reproducible experimental model for studying ureteral cicatrization in rabbits.
To investigate the temporal dynamics of ureteral wound healing post-surgery.
To provide a basis for evaluating therapeutic interventions in urological repair.

Summary:

A surgical lesion was created in rabbit ureters, followed by stent placement and repair.
Ureteral fragments were harvested at 1-6 days post-surgery to analyze healing.

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Last Updated: Jun 24, 2026

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction

Published on: April 4, 2025

Urethral Stricture Induction Followed by Buccal Mucosa Graft Urethroplasty in a Rat Model

Urethral Stricture Induction Followed by Buccal Mucosa Graft Urethroplasty in a Rat Model

Published on: April 28, 2023

Histological examination revealed inflammatory and fibrotic processes, including lumen constriction and subsequent resolution.

Impact:

The rabbit model mimics human ureteral healing patterns, albeit with different timing.
This model can aid in the development and testing of new urological therapies.
Understanding species-specific healing rates is crucial for accurate extrapolation to human clinical practice.