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Updated: Jun 24, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
[Development of polymeric micelles for the delivery of antitumor agents]
Nobuhiro Nishiyama1, Kazunori Kataoka
1Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo.
Abstract:
Recently, drug delivery systems(DDS)have received increasing attention as a medical application of nanotechnology. Among them, polymeric micelles, self-assemblies of block copolymers, are a promising nanocarrier, because they can incorporate a variety of therapeutic agents such as hydrophobic substances, metal complexes and charged macromolecular compounds. Also, polymeric micelles have been demonstrated to effectively accumulate in the tumor tissue and show remarkable antitumor efficacy. Indeed, polymeric micelles encapsulating adriamycin, paclitaxel, cisplatin and SN-38 have progressed to clinical trials. This review deals with the development strategy and recent progress of polymeric micelles for the delivery of chemotherapeutic agents.
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