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Polymorphisms of MMP-2 gene are associated with systolic heart failure risk in Han Chinese

Yihong Hua1, Li Song, Naqiong Wu

  • 1Department of Cardiology, Fu Wai Hospital, Beijing, China.

The American Journal of the Medical Sciences
|March 20, 2009
PubMed
Abstract

Insights

Genetic variations in Matrix metalloproteinases-2 (MMP-2) were studied for their association with systolic heart failure (HF) risk. The MMP-2 rs243866 A allele was linked to a reduced risk of developing systolic HF in the Han Chinese population.

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Matrix metalloproteinases (MMPs) are enzymes involved in protein degradation.
  • MMP-2 plays a key role in myocardial remodeling, a process implicated in congestive heart failure (HF).
  • Genetic variations in MMP-2 may influence the risk of developing systolic HF.

Purpose of the Study:

  • To investigate the association between specific single nucleotide polymorphisms (SNPs) of MMP-2 and the risk of systolic HF.
  • To determine if genetic variations in MMP-2 are predictive of systolic HF development.

Main Methods:

  • A hospital-based case-control study was conducted with 605 systolic HF patients and 689 controls.
  • Three MMP-2 SNPs (rs243864, rs243866, and rs17859821) were genotyped using restriction fragment length polymorphism (RFLP).
  • Statistical analyses included genotype frequency comparison and haplotype analysis.

Main Results:

  • The frequencies of MMP-2 rs243866 AA and AG genotypes were significantly higher in controls than in cases (P < 0.01).
  • Carriers of the MMP-2 rs243866 A allele showed a significantly lower risk of systolic HF compared to GG homozygotes (adjusted OR 0.69, P = 0.035).
  • Haplotype analysis revealed that the GGG haplotype (rs243864-rs17859821-rs243866) was associated with an increased risk of systolic HF (adjusted OR 2.05, P = 0.028).

Conclusions:

  • The MMP-2 rs243866 A allele is associated with a reduced risk of systolic heart failure.
  • These findings suggest a potential genetic marker for predicting systolic HF risk in the Han Chinese population.

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