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Updated: Jun 24, 2026

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

[Immune response in optic neuromyelitis].

I Lopategui Cabezas¹, M Cervantes Llano, G Pentón Rol

¹Departamento de Bioquímica, Instituto de Ciencias Básicas y Preclínicas Victoria de Girón, La Habana, Cuba.

Anales De Medicina Interna (Madrid, Spain : 1984)

|March 20, 2009

Summary

This summary is machine-generated.

Optic Neuromyelitis (ONM) is an autoimmune central nervous system disease. This review examines eosinophils, autoantibodies, and T cells in ONM pathogenesis, highlighting the crucial role of humoral response and TH2 immune cells.

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Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

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Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

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Published on: April 14, 2014

Area of Science:

Neuroimmunology
Autoimmune Diseases
Central Nervous System Disorders

Context:

Optic Neuromyelitis (ONM) is a severe inflammatory and autoimmune disorder affecting the central nervous system.
Understanding the intricate mechanisms of ONM pathogenesis is crucial for developing targeted therapies.

Purpose:

This work provides a comprehensive review of the key mechanisms driving Optic Neuromyelitis.
It specifically analyzes the roles of eosinophils, autoantibodies, and regulatory T cells in the disease's development.

Summary:

The review highlights the significant involvement of the humoral immune response in ONM.
Key features include immunocomplex deposition, complement activation, autoantibody production against myelin proteins, and eosinophil recruitment to lesions.
An increased expression of chemokine receptors, such as CCR3 specific for TH2 cells, indicates a predominant TH2-biased immune response in ONM.

Impact:

This review consolidates current knowledge on ONM pathogenesis, offering insights into potential therapeutic targets.
Understanding the interplay of immune cells and pathways can guide future research and clinical strategies for managing ONM.