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Soluble endothelial protein C receptor levels in healthy population

Filiz Simsek Orhon1, Huseyin Ergun, Yonca Egin

  • 1Department of Pediatrics, Division of Social Pediatrics, Ankara University School of Medicine, Ankara, Turkey. simsekfiliz@hotmail.com

Journal of Thrombosis and Thrombolysis
|March 20, 2009
PubMed

Insights

Soluble endothelial protein C receptor (sEPCR) levels are higher in children than adults, decreasing with age. This suggests a potential regulatory role for sEPCR in early life anticoagulation.

Area of Science:

  • Biochemistry
  • Hematology
  • Pediatrics

Background:

  • Soluble endothelial protein C receptor (sEPCR) plays a role in regulating coagulation.
  • Elevated sEPCR levels are associated with impaired EPCR-mediated coagulation.
  • Understanding sEPCR levels in healthy populations is crucial for interpreting its clinical significance.

Purpose of the Study:

  • To determine plasma sEPCR levels in a healthy Turkish population.
  • To investigate the relationship between plasma sEPCR levels and age in both children and adults.
  • To compare sEPCR levels between pediatric and adult healthy individuals.

Main Methods:

  • Plasma sEPCR levels were measured using Enzyme-Linked Immunosorbent Assay (ELISA).
  • The study included 230 healthy participants: 108 children and 122 adults.
  • Statistical analysis was performed to assess age-related differences and correlations.

Main Results:

  • Plasma sEPCR levels exhibited a bimodal distribution in both children and adults.
  • A significant negative correlation was observed between sEPCR levels and age (r = -0.385, P = 0.0001).
  • Children demonstrated significantly higher plasma sEPCR levels compared to adults (P < 0.001).

Conclusions:

  • This study is the first to report age-specific sEPCR levels and their relationship with age.
  • Higher sEPCR levels in children may indicate a regulatory mechanism for the protein C anticoagulation system during early life.
  • Further research is warranted to elucidate the physiological importance and molecular mechanisms of elevated sEPCR in children.

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