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Related Concept Videos

Cellular Injury IV: Necrosis01:16

Cellular Injury IV: Necrosis

Necrosis is a form of irreversible cell death caused by severe injury such as ischemia, toxins, or trauma. Unlike programmed cell death, it is an uncontrolled, pathological process that typically provokes inflammation in surrounding tissues.Pathophysiologic ChangesNecrosis begins when cells sustain critical damage, leading to swelling of organelles, particularly mitochondria, and rapid ATP depletion. As energy levels decline, membrane ion pumps fail, leading to calcium influx and eventually,...
Bones of the Lower Limb: Femur and Patella01:16

Bones of the Lower Limb: Femur and Patella

The femur is the body's longest and strongest bone spanning the thigh region. Its head articulates with the acetabulum of the hip bone to form the hip joint. A minor indentation on the medial side of the femoral head, called the fovea capitis, serves as the site of attachment for the ligament of the head of the femur. This weak ligament spans the femur and acetabulum and supports the hip joint. The narrowed region below the head is the neck of the femur. The inclination angle between the neck...
Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
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Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Diabetic Foot Ulcer01:31

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Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...

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Related Experiment Video

Updated: Jun 24, 2026

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats
05:55

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Published on: September 27, 2024

[Femoral head necrosis].

J Kramer1, G Scheurecker, A Scheurecker

  • 1Röntgeninstitut am Schillerpark, Linz, Osterreich. kramer@ctmri.at

Der Radiologe
|March 20, 2009
PubMed
Summary
This summary is machine-generated.

Avascular femoral head necrosis requires precise radiological evaluation for effective treatment. The ARCO staging system offers a detailed method for assessing this condition and comparing treatment outcomes.

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Area of Science:

  • Orthopedics
  • Radiology
  • Pathology

Context:

  • Avascular femoral head necrosis (AFHN) epidemiology and pathogenesis remain unclear.
  • AFHN progresses through stages, often requiring total hip replacement.
  • Accurate radiological assessment is crucial for guiding treatment decisions.

Purpose:

  • To detail the ARCO staging system for avascular femoral head necrosis.
  • To standardize radiological and histopathological evaluation of AFHN.
  • To facilitate comparison of treatment strategies and long-term results.

Summary:

  • The ARCO staging system provides a comprehensive framework for evaluating avascular femoral head necrosis.
  • It integrates radiological findings with histopathological alterations.
  • This system aids in consistent disease assessment and outcome analysis.

Impact:

  • Enables standardized comparison of different therapeutic approaches for AFHN.
  • Improves the evaluation of long-term treatment results.
  • Facilitates clearer understanding and management of avascular femoral head necrosis.