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Updated: Jun 24, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
Published on: October 11, 2014
Vitamin D receptor genotypes and kidney allograft rejection
Negar Azarpira1, Mohamad M Sagheb, Bita Geramizadeh
1Organ Transplant Research Center, Nemazi Hospital, Shiraz University of Medical Sciences, Zand Street, 7193711351 Shiraz, Iran. negarazarpira@yahoo.com
Objective:
Transplantation of renal grafts is an established treatment for renal failure in a variety of medical conditions. Polymorphisms in genes, coding for proteins involved in immune response, may influence immunological and non-immunological mechanisms that lead to allograft loss. Vitamin D receptor (VDR) agonist has been shown to reduce short and long term allograft rejection in animal model. There are functional polymorphisms in VDR gene.
Materials And Methods:
A total of 75 renal allograft recipients with at least 2 years follow-up were selected and genotyped for two polymorphisms in the VDR genes (FokI and BsmI) and the association of each genotype with renal allograft survival and acute rejection was evaluated.
Results:
We are unable to find statistically significant association between any of the study polymorphisms and clinical outcomes.
Conclusion:
We have found no evidence to suggest that either VDR FokI or BsmI polymorphism determines the incidence of acute rejection or graft survival after renal transplantation. A larger sample size is necessary to confirm these findings.
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