Related Experiment Videos
[Heart valves (anatomo-pathologic study of 1139 cases]
H R López Valle1, M T Alzaga, A Alvarez Aguilar
1Instituto Nacional de Cardiología Ignacio Chávez, Departmento de Anatomía-Patológica.
Archivos Del Instituto De Cardiologia De Mexico
|May 1, 1991
Summary
Pathological analysis of heart valves revealed rheumatic fever in 68% of native valves.国产 (INC) bovine pericardium valves showed an 82.2% survival rate and 3.38% dysfunction.
Area of Science:
- Cardiovascular Pathology
- Surgical Pathology
- Biomaterials Science
Context:
- Review of 1139 valvular replacement surgery cases from January 1983 to June 1988.
- Analysis of 1037 native valves and 186 prostheses.
- Focus on etiological diagnosis and prosthesis performance.
Purpose:
- To analyze pathological findings in native valves and explanted prostheses.
- To evaluate the performance and cost-effectiveness of domestically manufactured (INC) bovine pericardium valves.
- To compare the incidence of rheumatic fever and causes of prosthesis failure.
Summary:
- Rheumatic fever was confirmed in 68% of native valves; 32% lacked histological confirmation despite clinical diagnosis.
- Biological prosthesis failure was primarily due to calcification and fibrosis; mechanical prosthesis failure was due to thrombosis.
- 747 patients received 836 INC-manufactured bovine pericardium valves, demonstrating an 82.2% survival rate and 3.38% dysfunction rate over 4.5 years.
- INC prosthesis are significantly more cost-effective than imported mechanical prostheses, with price differences ranging from 1400% to 4000%.
Impact:
- Provides insights into the etiology of valvular heart disease and reasons for prosthesis failure.
- Highlights the clinical and economic advantages of domestically produced cardiovascular implants.
- Informs future strategies for valvular heart disease management and prosthetic valve selection.