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[Heart valves (anatomo-pathologic study of 1139 cases]

H R López Valle1, M T Alzaga, A Alvarez Aguilar

  • 1Instituto Nacional de Cardiología Ignacio Chávez, Departmento de Anatomía-Patológica.

Archivos Del Instituto De Cardiologia De Mexico
|May 1, 1991
PubMed

Insights

Pathological analysis of heart valves revealed rheumatic fever in 68% of native valves.国产 (INC) bovine pericardium valves showed an 82.2% survival rate and 3.38% dysfunction.

Area of Science:

  • Cardiovascular Pathology
  • Surgical Pathology
  • Biomaterials Science

Context:

  • Review of 1139 valvular replacement surgery cases from January 1983 to June 1988.
  • Analysis of 1037 native valves and 186 prostheses.
  • Focus on etiological diagnosis and prosthesis performance.

Purpose:

  • To analyze pathological findings in native valves and explanted prostheses.
  • To evaluate the performance and cost-effectiveness of domestically manufactured (INC) bovine pericardium valves.
  • To compare the incidence of rheumatic fever and causes of prosthesis failure.

Summary:

  • Rheumatic fever was confirmed in 68% of native valves; 32% lacked histological confirmation despite clinical diagnosis.
  • Biological prosthesis failure was primarily due to calcification and fibrosis; mechanical prosthesis failure was due to thrombosis.
  • 747 patients received 836 INC-manufactured bovine pericardium valves, demonstrating an 82.2% survival rate and 3.38% dysfunction rate over 4.5 years.
  • INC prosthesis are significantly more cost-effective than imported mechanical prostheses, with price differences ranging from 1400% to 4000%.

Impact:

  • Provides insights into the etiology of valvular heart disease and reasons for prosthesis failure.
  • Highlights the clinical and economic advantages of domestically produced cardiovascular implants.
  • Informs future strategies for valvular heart disease management and prosthetic valve selection.

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