Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hydrogen Bonds00:26

Hydrogen Bonds

Hydrogen BondsHydrogen bonds are weak attractions between atoms that have formed other chemical bonds. One of these atoms is electronegative, like oxygen, and has a partial negative charge. The other is a hydrogen atom that has bonded with another electronegative atom and has a partial positive charge.Hydrogen Bonds Control the World!Because hydrogen has very weak electronegativity when it binds with a strongly electronegative atom, such as oxygen or nitrogen, electrons in the bond are...
Hydrogen Bonds01:04

Hydrogen Bonds

A hydrogen bond is formed when a weakly positive hydrogen atom already bonded to one electronegative atom (for example, the oxygen in the water molecule) is attracted to another electronegative atom from another polar molecule, such as water (H2O), hydrogen fluoride (HF), or ammonia (NH3). The huge electronegativity difference between the H atom (2.1) and the atom to which it is bonded (4.0 for an F atom, 3.5 for an O atom, or 3.0 for an N atom), combined with the very small size of an H atom...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The cytoskeleton of pathogenic protists.

Bioscience reports·2026
Same author

Metal-metronidazole derivatives as potential antitrichomonal agents on Trichomonas vaginalis.

Experimental parasitology·2026
Same author

Breaking the ice - simplified freeze-fracture of parasitic protists: a cost-effective approach without highly specialised equipment.

Memorias do Instituto Oswaldo Cruz·2025
Same author

Looking Back to Move Forward: Tannic Acid in TEM of Parasitic Protozoa.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society·2025
Same author

Effects of cardanol-based phospholipid analogs on Trichomonas vaginalis.

Experimental parasitology·2024
Same author

Three-dimensional cellular architecture of the sigmoid filament in Trichomonas vaginalis.

Journal of structural biology·2024

Related Experiment Video

Updated: Jun 24, 2026

Visualization of Germinosomes and the Inner Membrane in Bacillus subtilis Spores
08:58

Visualization of Germinosomes and the Inner Membrane in Bacillus subtilis Spores

Published on: April 15, 2019

Hydrogenosomes under microscopy.

Marlene Benchimol1

  • 1Universidade Santa Ursula, Laboratório de Ultraestrutura Celular, Rio de Janeiro, Brazil. marleneben@uol.com.br

Tissue & Cell
|March 20, 2009
PubMed
Summary
This summary is machine-generated.

Hydrogenosomes are unique organelles related to mitochondria, found in various protozoa and fungi. Their distinct metabolism makes them promising drug targets for novel therapies.

More Related Videos

Mitochondria and Endoplasmic Reticulum Imaging by Correlative Light and Volume Electron Microscopy
09:21

Mitochondria and Endoplasmic Reticulum Imaging by Correlative Light and Volume Electron Microscopy

Published on: July 20, 2019

Visualization of Organelles In Situ by Cryo-STEM Tomography
08:37

Visualization of Organelles In Situ by Cryo-STEM Tomography

Published on: June 23, 2023

Related Experiment Videos

Last Updated: Jun 24, 2026

Visualization of Germinosomes and the Inner Membrane in Bacillus subtilis Spores
08:58

Visualization of Germinosomes and the Inner Membrane in Bacillus subtilis Spores

Published on: April 15, 2019

Mitochondria and Endoplasmic Reticulum Imaging by Correlative Light and Volume Electron Microscopy
09:21

Mitochondria and Endoplasmic Reticulum Imaging by Correlative Light and Volume Electron Microscopy

Published on: July 20, 2019

Visualization of Organelles In Situ by Cryo-STEM Tomography
08:37

Visualization of Organelles In Situ by Cryo-STEM Tomography

Published on: June 23, 2023

Area of Science:

  • Cell Biology
  • Organelle Research
  • Microbiology

Background:

  • Hydrogenosomes are hydrogen-producing organelles evolutionarily linked to mitochondria.
  • Found in Parabasalia protozoa, chytrid fungi, and ciliates, they share similarities and differences with mitochondria.
  • These organelles are typically 200 nm to 1 micrometer in size, enclosed by double membranes with a granular matrix.

Purpose of the Study:

  • To detail the structural and functional characteristics of hydrogenosomes.
  • To explore their relationship with mitochondria and their unique cellular roles.
  • To highlight their potential as therapeutic targets due to distinct metabolic pathways.

Main Methods:

  • Morphological analysis of hydrogenosome size and shape.
  • Biochemical detection of membrane components like cardiolipin and proteins like frataxin.
  • Investigation of hydrogenosome division mechanisms and cellular interactions (e.g., autophagy, lysosomal digestion).

Main Results:

  • Hydrogenosomes possess double membranes, a granular matrix, and contain cardiolipin and frataxin.
  • Peripheral vesicles involved in calcium incorporation represent a distinct hydrogenosomal compartment.
  • Hydrogenosomes divide via segmentation, partition, and the heart form, independent of the cell cycle stage.

Conclusions:

  • Hydrogenosomes exhibit unique structural and biochemical features, differentiating them from mitochondria.
  • Their distinct metabolic pathways offer significant potential as drug targets.
  • Understanding hydrogenosome biology is crucial for developing targeted therapies against organisms harboring them.