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A study of profile of ventilator-associated pneumonia in children in Punjab

Harsh Sharma1, Daljit Singh, Puneet Pooni

  • 1Department of Pediatrics, Indira Gandhi Memorial Hospital, Male, Maldives. dr_harsh75@yahoo.co.in

Journal of Tropical Pediatrics
|March 20, 2009
PubMed

Insights

The use of H(2) blockers like Ranitidine for over two days in children requiring mechanical ventilation was linked to a higher incidence of ventilator-associated pneumonia (VAP). This finding highlights a potential risk factor for VAP in pediatric intensive care units.

Area of Science:

  • Pediatric critical care medicine
  • Infectious disease epidemiology
  • Respiratory medicine

Background:

  • Ventilator-associated pneumonia (VAP) is a significant nosocomial infection in pediatric intensive care units (PICUs).
  • Identifying modifiable risk factors for VAP is crucial for improving patient outcomes.

Purpose of the Study:

  • To determine the incidence, risk factors, outcomes, and microbial patterns of VAP in children.
  • To investigate the association between specific medications and VAP development.

Main Methods:

  • A prospective cohort study was conducted in a Level III PICU.
  • Included were children aged 1 month to 15 years requiring mechanical ventilation for at least 48 hours.
  • VAP diagnosis followed established clinical criteria.

Main Results:

  • The incidence of VAP was 20% (8 out of 40 patients).
  • Prolonged use (>2 days) of H(2) blockers (Ranitidine) was significantly associated with VAP development.
  • Other investigated factors did not show a significant relationship with VAP.

Conclusions:

  • The use of H(2) blockers, specifically Ranitidine, is associated with an increased incidence of VAP in pediatric patients.
  • This suggests a potential target for VAP prevention strategies in this population.
Abstract

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