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Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
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DASher: a stand-alone protein sequence client for DAS, the Distributed Annotation System.

David N Messina1, Erik L L Sonnhammer

  • 1Stockholm Bioinformatics Centre, Stockholm University, 10691 Stockholm, Sweden.

Bioinformatics (Oxford, England)
|March 20, 2009
PubMed
Summary
This summary is machine-generated.

DASher is a new open-source Java client for the Distributed Annotation System (DAS). It integrates and compares protein sequence annotations from multiple databases in a standalone application.

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • The increasing volume of biological sequence data necessitates integrated annotation views.
  • Specialized databases offer valuable but fragmented information.
  • The Distributed Annotation System (DAS) was developed to address data integration challenges.

Purpose of the Study:

  • To develop an open-source, standalone DAS client for aggregating and comparing protein sequence annotations.
  • To provide a flexible and extensible alternative to web-browser-based DAS clients.
  • To create a tool optimized for viewing protein sequence data.

Main Methods:

  • Developed DASher, a Java-based DAS client.
  • Implemented support for the latest DAS protocol specification (1.53E).
  • Designed DASher to query DAS-supporting servers globally using UniProt identifiers.

Main Results:

  • DASher provides an interactive viewer for comparing protein sequence annotations.
  • The client automatically retrieves annotations from worldwide DAS servers.
  • It functions as a self-contained application, independent of web browsers.

Conclusions:

  • DASher offers a fast, flexible, and extensible solution for protein sequence annotation integration.
  • It addresses the need for open-source, standalone DAS clients.
  • The tool facilitates easier comparison of diverse biological sequence data.