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Updated: Jun 24, 2026

Three Strategies to Induce Neurotrophic Keratitis and Nerve Regeneration in Murine Cornea
06:10

Three Strategies to Induce Neurotrophic Keratitis and Nerve Regeneration in Murine Cornea

Published on: December 8, 2023

New pyrenochaeta species causing keratitis.

Consuelo Ferrer1, Juan J Pérez-Santonja, Alejandra E Rodríguez

  • 1Research & Development Department, Ophthalmology Division, Vissum Corporation, Instituto Oftalmológico de Alicante, Universidad Miguel Hernández, Alicante, Spain. cferrer@vissum.com

Journal of Clinical Microbiology
|March 20, 2009
PubMed
Summary

A new fungal species, Pyrenochaeta, caused fungal keratitis in a diabetic patient. Diagnosis involved microbiology and PCR, confirming a novel Pyrenochaeta species after antibacterial treatment failure.

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Last Updated: Jun 24, 2026

Three Strategies to Induce Neurotrophic Keratitis and Nerve Regeneration in Murine Cornea
06:10

Three Strategies to Induce Neurotrophic Keratitis and Nerve Regeneration in Murine Cornea

Published on: December 8, 2023

Area of Science:

  • Mycology
  • Ophthalmology
  • Infectious Diseases

Background:

  • Fungal keratitis is an infection of the cornea.
  • Diabetic patients are at increased risk for fungal infections.
  • Accurate identification of fungal pathogens is crucial for effective treatment.

Observation:

  • A diabetic woman presented with persistent corneal infection despite antibacterial therapy.
  • Standard microbiological methods and Polymerase Chain Reaction (PCR) were used for diagnosis.
  • The isolate exhibited unique morphological characteristics.

Findings:

  • A novel species of Pyrenochaeta (Coelomycetes) was identified as the causative agent of fungal keratitis.
  • Morphological analysis and internal transcribed spacer (ITS) sequence data confirmed the new species.
  • The fungus remained pathogenic even after prolonged antibacterial treatment.

Implications:

  • This finding expands the known spectrum of fungal keratitis agents.
  • Highlights the importance of considering fungal etiology in refractory keratitis, especially in diabetics.
  • Emphasizes the need for advanced molecular techniques for accurate fungal species identification in clinical settings.