Related Experiment Video
Updated: Jun 24, 2026
08:01
A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells
Published on: August 29, 2020
Sheng Ding: using chemical methods to control cell fate.
ACS Chemical Biology
|March 21, 2009
Summary
Explore scientist profiles detailing career paths and futures. Submit your questions to experts on ACS Chemical Biology's online platform for featured exchanges.
Area of Science:
- Chemical Biology
- Scientific Communication
Background:
- Profiles feature scientists from ACS Chemical Biology's Ask the Expert series.
- Content focuses on personal lives, career trajectories, and future research directions.
Discussion:
- The Ask the Expert feature facilitates direct engagement between readers and scientists.
- Selected Q&A exchanges will be published online, highlighting key scientific discussions.
Key Insights:
- Provides a unique window into the scientific community and individual researcher journeys.
- Encourages broader understanding of careers in chemical biology.
Outlook:
- Dr. Ding will commence answering questions in mid-March 2009.
- Readers are invited to submit questions via the community portal to foster scientific dialogue.
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01:24Methods of Nuclear Reprogramming
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.
01:51Determination
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...