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Published on: May 17, 2019
Peroxiredoxin I is overexpressed in oncocytic lesions of salivary glands
Ana P D Demasi1, Cristiane Furuse, Albina Altemani
1Department of Oral Pathology, São Leopoldo Mandic Research Center, SP, Brazil. demasiap@gmail.com
Background:
Oncocytic lesions, particularly frequent in the salivary glands, are characterized by cells with an atypical accumulation of mitochondria. This accumulation has been recognized as a compensatory mechanism to intrinsic functional defects of these organelles, resulting in energy production impairment and increased generation of reactive oxygen species (ROS), including hydrogen peroxide (H(2)O(2)). Peroxiredoxin I (Prx I) is a H(2)O(2) scavenging protein and the expression of its yeast homolog was reported to be influenced by mitochondrial function.
Methods:
In this study, we evaluated Prx I expression in oncocytic lesions of salivary glands by immunohistochemistry.
Results:
Our results showed that Prx I is overexpressed in oncocytes regardless of the salivary gland lesion where they appear.
Conclusions:
These results suggest that Prx I expression in oncocytes is related to its ability to decompose mitochondrial-derived H(2)O(2) and that it could provide to the cells a protective role in an environment that, by continuously producing potential DNA-damaging ROS, predisposes to genome instability and cellular transformation.
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