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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Healing II: Complications

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Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
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Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Hand dermatitis and lymphoedema.

V J Pearce1, P S Mortimer

  • 1Lymphoedema Service, Department of Dermatology, St George's Hospital, London SW17 0QT, UK. torijpearce@yahoo.com.au

The British Journal of Dermatology
|March 21, 2009
PubMed
Summary
This summary is machine-generated.

Hand dermatitis can rarely cause lymphoedema (swelling) due to lymphatic system issues. Controlling both infection and eczema inflammation is key for effective treatment and reducing swelling.

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Area of Science:

  • Dermatology
  • Lymphology
  • Immunology

Background:

  • Hand dermatitis is a common condition.
  • Lymphoedema of the hand and forearm is a rare but challenging complication.
  • The underlying mechanisms of dermatitis-associated lymphoedema are not well understood.

Observation:

  • Nine patients with dermatitis-associated lymphoedema were studied.
  • Most patients had long-standing bilateral pompholyx eczema.
  • Recurrent infections were common after swelling onset.

Findings:

  • Lymphoscintigraphy showed impaired lymphatic absorption and drainage in affected hands.
  • Possible mechanisms include infection-induced lymphangitis, dermatitis inflammation, or lymphatic system weakness.
  • Successful treatment requires controlling both infection and dermatitis inflammation.

Implications:

  • Aggressive management of dermatitis and prophylactic antibiotics are crucial.
  • Systemic therapy for eczema may be necessary.
  • Understanding these mechanisms can guide better management strategies for this rare complication.