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Lymphoid Cells and Tissues

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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
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Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis

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Infectious agents and lymphoma development: molecular and clinical aspects.

A J M Ferreri¹, I Ernberg, C Copie-Bergman

¹Unit of Lymphoid Malignancies, Medical Oncology Unit, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy. andres.ferreri@hsr.it

Journal of Internal Medicine

|March 21, 2009

Summary

Infectious agents like bacteria and viruses are linked to specific lymphomas. This review examines Helicobacter pylori, Chlamydophila psittaci, Borrelia burgdorferi, and Epstein-Barr virus in lymphoma development.

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Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis

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Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

Area of Science:

Oncology
Infectious Diseases
Immunology

Background:

Infectious agents are increasingly recognized for their role in various cancers.
Specific microbial infections have been associated with certain types of lymphomas, particularly marginal zone B-cell lymphomas.

Purpose of the Study:

To review the role of infectious agents in the development of specific lymphoma entities.
To discuss the molecular, biological, clinical, and therapeutic implications of these associations.

Main Methods:

Literature review of studies investigating infectious agents and lymphomas.
Analysis of associations between specific bacteria (Helicobacter pylori, Chlamydophila psittaci, Borrelia burgdorferi) and MALT lymphomas.
Examination of Epstein-Barr virus's role in lymphoproliferative disorders.

Main Results:

Strong associations exist between bacterial infections and mucosa-associated lymphoid tissue (MALT) lymphomas, including H. pylori with gastric MALT lymphoma, C. psittaci with ocular adnexal MALT lymphomas, and B. burgdorferi with cutaneous MALT lymphomas.
Epstein-Barr virus (EBV) is a significant lymphotropic virus with demonstrated tumorigenic activity, linked to various lymphoproliferative disorders.

Conclusions:

Infectious agents play a critical role in the pathogenesis of several lymphoma types.
Understanding these associations is crucial for developing targeted therapies and future research directions in lymphoma treatment.