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Updated: Jun 24, 2026

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Published on: June 13, 2018

Cutaneous sarcoidosis: a histopathological study.

J C Cardoso¹, M Cravo, J P Reis

¹Dermatology Department, Coimbra University Hospital, Coimbra, Portugal. ze_carlos_cardoso@yahoo.com.br

Journal of the European Academy of Dermatology and Venereology : JEADV

|March 21, 2009

Summary

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Cutaneous sarcoidosis often shows typical naked granulomas. However, atypical findings like lymphocytic infiltration and epidermal changes are common, requiring careful dermatopathology for differential diagnosis.

Area of Science:

Dermatopathology
Granulomatous Diseases

Background:

Sarcoidosis is a granulomatous disease with frequent skin involvement.
Naked sarcoidal granulomas are the hallmark histological feature of sarcoidosis lesions.

Purpose of the Study:

To describe the histological findings in patients with cutaneous sarcoidosis.
To highlight the spectrum of histological presentations in skin sarcoidosis.

Main Methods:

Retrospective analysis of 31 biopsies from 30 patients with cutaneous sarcoidosis.
Histopathological examination of specific lesions.

Main Results:

Typical naked granulomas observed in 71% of cases.
Atypical features included lymphocytic granulomas (29%), necrosis (6%), periadnexal/perisudoral distribution (32%), interstitial granulomas (16%), and foreign material (13%).

Related Experiment Videos

Last Updated: Jun 24, 2026

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Published on: June 13, 2018

Epidermal changes (atrophy, parakeratosis) noted in 55% of cases.

Conclusions:

While typical naked granulomas are prevalent, awareness of atypical findings in cutaneous sarcoidosis is crucial.
Atypical histological features are more common than previously thought.
Dermatopathologists must consider differential diagnoses, especially infectious causes of granulomas.