Cerebral vasospasm following subarachnoid hemorrhage: time for a new world of thought
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Updated: Jun 24, 2026

Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound
Published on: June 3, 2021
Ryszard M Pluta1, Jacob Hansen-Schwartz, Jens Dreier
1Department of Neurosurgery, Loma Linda University Medical Center, Loma Linda, CA 92354, USA.
Objective:
Delayed cerebral vasospasm has long been recognized as an important cause of poor outcome after an otherwise successful treatment of a ruptured intracranial aneurysm, but it remains a pathophysiological enigma despite intensive research for more than half a century.
Method:
Summarized in this review are highlights of research from North America, Europe and Asia reflecting recent advances in the understanding of delayed ischemic deficit.
Result:
It will focus on current accepted mechanisms and on new frontiers in vasospasm research.
Conclusion:
A key issue is the recognition of events other than arterial narrowing such as early brain injury and cortical spreading depression and of their contribution to overall mortality and morbidity.
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