Related Experiment Video
Updated: Jun 24, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
The IL-16 gene polymorphisms and the risk of the systemic lupus erythematosus
Hui Xue1, Linbo Gao, Yongkang Wu
1Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, 610041, Sichuan, PR China.
Background:
Interleukin 16 (IL-16) is an immunomodulatory cytokine which plays an important role in many inflammatory and autoimmune diseases. We determined the association between SNPs of IL-16 gene (i.e. rs11556218 G/T, rs4778889 C/T, and rs4072111 C/T) and systemic lupus erythematosus (SLE).
Methods:
One hundred thirty-eight SLE patients and 199 controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing assay.
Results:
In the SLE group, the individuals carrying the G allele of rs11556218, the C allele of rs4778889 and the T allele of rs4072111 are at a significantly higher risk of SLE as compared with those carrying the T allele of rs11556218, the T allele of rs4778889, and the C allele of rs4072111 respectively (for rs11556218, OR=2.264, 95% CI, 1.64-3.127; for rs4778889, OR=1.927, 95%CI, 1.359-2.731; and for rs4072111, OR=2.417, 95% CI, 1.691-3.455).
Conclusions:
The IL-16 gene polymorphisms may be associated with the risk of SLE.
Related Concept Videos
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Non-LTR Retrotransposons
Single Nucleotide Polymorphisms-SNPs
Principles of Pharmacogenetics: Types of Genetic Variants
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters
