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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.

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Related Experiment Video

Updated: Jun 24, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

Histocompatibility methods.

Kathryn Tinckam1

  • 1Departments of Laboratory Medicine and Pathobiology and Medicine, University of Toronto, Toronto ON, Canada M5G 1L5. Kathryn.Tinckam@uhn.on.ca

Transplantation Reviews (Orlando, Fla.)
|March 21, 2009
PubMed
Summary
This summary is machine-generated.

Histocompatibility testing predicts transplant rejection risk by analyzing donor compatibility and detecting anti-human leukocyte antigen antibodies. Understanding these tests is crucial for solid organ transplant recipients.

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Published on: November 28, 2018

Area of Science:

  • Immunology
  • Transplantation Medicine
  • Medical Diagnostics

Background:

  • Histocompatibility testing is vital for predicting humoral alloimmune potential in transplant recipients.
  • Accurate donor typing and sensitive antibody testing are essential for successful transplantation.

Purpose of the Study:

  • To review the evolution and current practices of histocompatibility testing methods.
  • To discuss novel methods for measuring T-cell alloimmune potential.
  • To emphasize clinical applicability and limitations of tests for immunologic risk assessment.

Main Methods:

  • Review of historical and current histocompatibility testing techniques.
  • Description of methods for human leukocyte antigen typing.
  • Overview of antibody screening and crossmatching procedures.

Main Results:

  • Current practices involve typing, crossmatching, and antibody screening for risk assessment.
  • Novel methods for T-cell alloimmune potential are emerging.
  • Clinical applicability and limitations of each test are considered.

Conclusions:

  • Comprehensive histocompatibility testing is key to managing immunologic risk in solid organ transplant recipients.
  • Integrating various testing modalities enhances the accuracy of risk assessment.
  • Understanding test limitations is crucial for effective clinical decision-making.