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Updated: Jun 24, 2026
04:23
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Dengue encephalitis: an entity now common in dengue-prone regions
Monica Matlani1, Anita Chakravarti, Ashish Rawal
1Department of Microbiology, Maulana Azad Medical College, Flat No. C-402, Vimal CGHS Ltd, Plot No. 03, Sector-12, Dwarka, New Delhi 110075, India.
Tropical Doctor
|March 21, 2009
Summary
Dengue virus infection can cause unusual symptoms, including central nervous system (CNS) involvement. This study reports two cases of encephalitis, a serious brain inflammation, linked to dengue fever and dengue hemorrhagic fever in India.
Area of Science:
- Neurology
- Infectious Diseases
- Virology
Background:
- Dengue virus infection presents with typical symptoms like dengue fever (DF) and severe dengue hemorrhagic fever-dengue shock syndrome (DHF/DSS).
- Atypical manifestations of dengue virus infection are increasingly recognized.
- The exact frequency of central nervous system (CNS) involvement during dengue remains unclear, despite reported cases of neurological complications globally.
Observation:
- This report details two cases of encephalitis occurring in conjunction with dengue virus infection.
- The cases originated from New Delhi, India, highlighting a specific geographical context.
- Both patients exhibited neurological symptoms indicative of CNS involvement.
Findings:
- The study identifies encephalitis as a potential neurological manifestation of dengue.
- The findings contribute to understanding the spectrum of dengue virus disease.
- These cases underscore the importance of considering dengue in the differential diagnosis of encephalitis, particularly in endemic regions.
Implications:
- Increased awareness of CNS involvement in dengue can lead to earlier diagnosis and management of neurological complications.
- Further research is warranted to determine the prevalence and pathogenic mechanisms of dengue-associated encephalitis.
- This study contributes to the global understanding of dengue's neurological impact.
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