Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Pituitary Gland

The Pituitary Gland

The pituitary is a small endocrine organ in the sphenoid bone under the hypothalamus. Primarily, the pituitary in adults has two distinct anatomical and functional regions— the anterior and posterior lobes. During human fetal development, a third pituitary gland region called the pars intermedia atrophies and disappears. However, some of its cells migrate and exist adjacent to the anterior pituitary in adults.

Development of the Sexual Organs in the Embryo and Fetus

Development of the Sexual Organs in the Embryo and Fetus

Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the male...

Nondisjunction

Nondisjunction

Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers. Nondisjunction is common during anaphase I or anaphase II of meiosis. Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...

Nondisjunction

Nondisjunction

During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Experimental scatter of the fatigue response of additively manufactured components: a statistical method based on the Profile Likelihood.

Scientific reports·2023

Same author

Prognostic role and interaction of TERT promoter status, telomere length and MGMT promoter methylation in newly diagnosed IDH wild-type glioblastoma patients.

ESMO open·2023

Same author

Magnetic resonance T1w/T2w ratio and voxel-based morphometry in multiple system atrophy.

Scientific reports·2021

Same author

Indication to dynamic and invasive testing in Cushing's disease according to different neuroradiological findings.

Journal of endocrinological investigation·2021

Same author

Multishell Diffusion MRI-Based Tractography of the Facial Nerve in Vestibular Schwannoma.

AJNR. American journal of neuroradiology·2020

Same author

S100B as a new fecal biomarker of inflammatory bowel diseases.

European review for medical and pharmacological sciences·2020

Same journal

CT Evaluation of Osseous Trauma at the Craniocervical Junction: A Pattern-Based Overview.

AJNR. American journal of neuroradiology·2026

Same journal

Comprehensive Structural MRI Phenotyping in <i>Oligophrenin 1-</i>Related Disorder Reveals Characteristic Brain Malformations.

AJNR. American journal of neuroradiology·2026

Same journal

ASNR-ESNR White Paper on Sustainability in Neuroradiology.

AJNR. American journal of neuroradiology·2026

Same journal

Intracranial Atherosclerotic Disease Distribution Across Circle of Willis Segments: Insights from CREST-H.

AJNR. American journal of neuroradiology·2026

Same journal

Regional Cerebral Blood Flow Patterns on ASL in Subacute Sclerosing Panencephalitis: Quantitative Analysis and Clinical Correlation.

AJNR. American journal of neuroradiology·2026

Same journal

Improved Diagnostic Certainty of Photon-Counting CT Myelography Compared with Energy-Integrating CT for CSF-Venous Fistulas in Spontaneous Intracranial Hypotension.

AJNR. American journal of neuroradiology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 24, 2026

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Published on: April 12, 2024

Hypophyseal triplication: case report and embryologic considerations.

R Manara¹, V Citton, M Rossetto

¹Neuroradiologic Unit, University Hospital of Padua, Padua, Italy. renzo.manara@sanita.padova.it

AJNR. American Journal of Neuroradiology

|March 21, 2009

Summary

This summary is machine-generated.

This study describes a rare pituitary gland malformation, termed hypophyseal triplication, observed in a newborn. This unique case offers insights into pituitary development and embryogenesis.

More Related Videos

Dissection and Coronal Slice Preparation of Developing Mouse Pituitary Gland

Dissection and Coronal Slice Preparation of Developing Mouse Pituitary Gland

Published on: November 16, 2017

Related Experiment Videos

Last Updated: Jun 24, 2026

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Published on: April 12, 2024

Dissection and Coronal Slice Preparation of Developing Mouse Pituitary Gland

Dissection and Coronal Slice Preparation of Developing Mouse Pituitary Gland

Published on: November 16, 2017

Area of Science:

Developmental Biology
Neuroendocrinology
Congenital Malformations

Background:

The pituitary gland is crucial for endocrine regulation.
Embryogenesis of the pituitary involves complex signaling pathways.
Midline abnormalities can indicate underlying developmental defects.

Observation:

A newborn presented with midline abnormalities and underwent epignathus excision.
Brain MRI revealed a previously undescribed pituitary malformation: hypophyseal triplication.
The malformation consisted of two paired lateral pituitary glands and one midline gland, each with a distinct stalk.

Findings:

The three pituitary glands were connected to a thickened third ventricle floor.
Each gland possessed an independent stalk, suggesting a unique developmental origin.
This represents the first documented case of hypophyseal triplication.

Implications:

This case provides novel insights into the embryogenesis of the pituitary gland.
Understanding such malformations can refine diagnostic approaches for midline defects.
Further research may elucidate the genetic and developmental factors involved in pituitary formation.