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Related Experiment Video

Updated: Jun 24, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

Bladder cancer: modeling and translation.

Jonathan E Rosenberg1, William C Hahn

  • 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA. Jonathan_Rosenberg@dfci.harvard.edu

Genes & Development
|March 21, 2009
PubMed
Summary
This summary is machine-generated.

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Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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A new genetically engineered mouse model mimics human bladder cancer, aiding research into this common malignancy. This model offers insights into the disease

Area of Science:

  • Oncology
  • Genetics
  • Cancer Biology

Background:

  • Transitional cell carcinoma of the bladder is a prevalent malignancy with significant health impacts worldwide.
  • Superficial bladder tumors are treatable, but invasive cancers are resistant to standard therapies, necessitating invasive surgery.

Discussion:

  • Puzio-Kuter and colleagues introduce a genetically engineered mouse model of bladder cancer.
  • This model effectively replicates key characteristics of human bladder cancer, facilitating further study.

Key Insights:

  • The development of advanced models is crucial for understanding bladder cancer's molecular underpinnings.
  • Enumerating genetic alterations in bladder cancer using new methods will yield significant insights.

Outlook:

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An Orthotopic Model of Murine Bladder Cancer
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An Orthotopic Model of Murine Bladder Cancer

Published on: February 6, 2011

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Last Updated: Jun 24, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

An Orthotopic Model of Murine Bladder Cancer
09:07

An Orthotopic Model of Murine Bladder Cancer

Published on: February 6, 2011

  • The unique anatomy of bladder cancer presents opportunities for novel translational research.
  • This model system will advance the study of bladder cancer genetics and treatment strategies.