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Updated: Jun 24, 2026

Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage
09:41

Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage

Published on: July 3, 2014

Serum cholesterol LDL and 90-day mortality in patients with intracerebral hemorrhage

José María Ramírez-Moreno1, Ignacio Casado-Naranjo, Juan Carlos Portilla

  • 1Department of Neurology, Section of Neurology, Infanta Cristina Universitary Hospital, Badajoz, Spain. jramirezm@meditex.es

Stroke
|March 21, 2009
PubMed

Insights

Low low-density lipoprotein cholesterol (LDL-C) levels are linked to increased mortality risk in patients with intracranial hemorrhage (ICH). This study found low LDL-C independently predicts death in ICH survivors.

Area of Science:

  • Neurology
  • Cardiovascular Science
  • Critical Care Medicine

Background:

  • The prognostic value of low-density lipoprotein cholesterol (LDL-C) in patients with intracranial hemorrhage (ICH) remains incompletely understood.
  • Investigating LDL-C's role is crucial for understanding ICH outcomes.

Purpose of the Study:

  • To determine the association between LDL-C levels and mortality in patients diagnosed with ICH.

Main Methods:

  • A cohort of 88 ICH patients had their lipid profiles assessed within hours of admission.
  • Statistical analyses included Cox proportional hazards models and Mantel-Haenszel tests to evaluate LDL-C's impact on 90-day mortality.
  • Spearman correlation was used to explore associations between LDL-C and ICH severity markers.

Main Results:

  • Low LDL-C levels were independently associated with a significantly increased risk of 90-day mortality (HR=3.07; P=0.042) after adjusting for confounders.
  • Trend analysis confirmed a significant association between lower LDL-C and mortality (P=0.032).
  • No significant correlation was found between LDL-C levels and ICH severity markers such as NIH score, GCS score, ICH volume, or length of stay.

Conclusions:

  • Low LDL-C levels are an independent predictor of increased mortality in patients with brain hemorrhage.
  • LDL-C levels did not appear to serve as a reliable biological marker for ICH severity in this cohort.
Abstract

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