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Related Concept Videos

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Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
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Related Experiment Video

Updated: Jun 24, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

Interferon and heart disease.

Allan D Angerio1

  • 1School of Nursing and Health Studies, Georgetown University, Washington, DC 20057, USA. angerioa@georgetown.edu

Critical Care Nursing Quarterly
|March 21, 2009
PubMed
Summary

Interferon gamma plays a key role in atherosclerosis, a chronic inflammatory condition driving heart disease. Understanding this immune response is crucial for developing new treatments for cardiovascular disease.

Area of Science:

  • Cardiovascular Science
  • Immunology
  • Inflammation Biology

Background:

  • Heart disease remains the primary cause of death and illness in the US.
  • Atherosclerosis, a major contributor to heart disease, is characterized by chronic inflammation.
  • Multiple factors are implicated in the development of this inflammatory process.

Purpose of the Study:

  • To review the specific role of interferon gamma in the pathogenesis of atherosclerosis.
  • To explore the mechanisms by which interferon gamma influences chronic inflammation in the context of cardiovascular disease.

Main Methods:

  • Literature review of existing research on interferon gamma and atherosclerosis.
  • Analysis of studies investigating inflammatory pathways in cardiovascular disease.

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Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
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Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

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Last Updated: Jun 24, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

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Published on: March 24, 2015

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08:09

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08:26

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

Published on: June 14, 2018

  • Synthesis of data on the molecular and cellular functions of interferon gamma in atherogenesis.

    • Main Results:

    • Interferon gamma is identified as a significant mediator of chronic inflammation in atherosclerosis.
    • Evidence suggests interferon gamma influences key processes in plaque development and progression.
    • The review consolidates findings on interferon gamma's impact on immune cell function and inflammatory signaling in the arterial wall.

    Conclusions:

    • Interferon gamma is a critical cytokine in the inflammatory cascade of atherosclerosis.
    • Targeting interferon gamma pathways presents a potential therapeutic strategy for heart disease.
    • Further research is warranted to fully elucidate the therapeutic potential of modulating interferon gamma in cardiovascular conditions.