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Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

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Published on: November 8, 2018

Gabapentin-induced coma: A MR-spectrometry analysis.

Lamine Abdennour¹, Paola Sanchez-Peña, Damien Galanaud

¹Staff Anesthesiologist, Department of Anesthesiology and Critical Care.

Neuropsychiatric Disease and Treatment

|March 21, 2009

Summary

This summary is machine-generated.

Gabapentin can cause encephalopathy, a brain dysfunction. This report details a rare case of gabapentin-induced coma, highlighting the use of magnetic resonance-spectrometry for diagnosis.

Keywords:

MR-spectrometry antiepileptic drugs encephalopathy gabapentin

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Area of Science:

Neurology
Pharmacology
Neuroimaging

Background:

Encephalopathy is a known side effect of many antiepileptic drugs.
Gabapentin is an antiepileptic medication.
Information regarding gabapentin-induced coma is scarce in medical literature.

Observation:

A patient presented with symptoms suggestive of encephalopathy.
The patient had recently been treated with gabapentin.
Magnetic resonance-spectrometry (MRS) was utilized as part of the diagnostic workup.

Findings:

The case represents the third documented instance of gabapentin-induced coma.
Magnetic resonance-spectrometry provided valuable data for assessing the patient's condition.
This finding underscores a rare but serious adverse effect of gabapentin.

Implications:

Clinicians should consider gabapentin-induced coma in patients presenting with unexplained encephalopathy, especially after gabapentin initiation.
Magnetic resonance-spectrometry may aid in the diagnosis of this rare condition.
Further research is warranted to understand the mechanisms and prevalence of gabapentin-induced coma.