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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

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[Operative risk of geriatric patients in cardiac surgery].

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[Refeeding syndrome : Pathophysiology, risk factors, prevention, and treatment].

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Prevalence of Risk Factors for the Refeeding Syndrome in Older Hospitalized Patients.

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Health Promotion and Preventive Care Intervention for Older Community-Dwelling People: Long-Term Effects of a Randomised Controlled Trial (RCT) within the LUCAS Cohort.

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Correction to: The MINDMAP project: mental well-being in urban environments : Design and first results of a survey on healthcare planning policies, strategies and programmes that address mental health promotion and mental disorder prevention for older people in Europe.

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The MINDMAP project: mental well-being in urban environments : Design and first results of a survey on healthcare planning policies, strategies and programmes that address mental health promotion and mental disorder prevention for older people in Europe.

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Related Experiment Video

Updated: Jun 24, 2026

Using Motion Capture Technology in the Instrumented Timed Up and Go Test to Detect the Risk of Falling in Aged Adults
05:26

Using Motion Capture Technology in the Instrumented Timed Up and Go Test to Detect the Risk of Falling in Aged Adults

Published on: October 25, 2024

[Medication and falls in old age].

M K Modreker1, W von Renteln-Kruse

  • 1Medizinisch-Geriatrische Klinik, Albertinen-Haus, Zentrum für Geriatrie und Gerontologie, Wiss. Einrichtung an der Universität Hamburg, Sellhopsweg 18-22, Hamburg, Germany.

Der Internist
|March 21, 2009
PubMed
Summary

Falls in the elderly are often caused by medications. Reducing or stopping fall-risk increasing drugs (FRIDs) can lower fall risk, but more research is needed on how drugs improve mobility.

Area of Science:

  • Gerontology
  • Pharmacology
  • Public Health

Context:

  • Falls are a major health concern for elderly individuals, often resulting from multifactorial causes.
  • Medication use, including prescription and over-the-counter drugs, is a significant contributing factor to falls in older adults.
  • Frail elderly individuals on multiple medications are especially vulnerable to adverse drug effects that increase fall risk.

Purpose:

  • To highlight the essential role of comprehensive drug assessment in fall prevention strategies for the elderly.
  • To identify specific drug classes, such as psychotropic and cardiovascular medications, that increase fall risk.
  • To review the success of interventions involving drug withdrawal or dose reduction in mitigating fall risk.

Summary:

  • Adverse drug effects, particularly dose-dependent effects of psychotropic and cardiovascular medications, contribute significantly to falls in the elderly.

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Related Experiment Videos

Last Updated: Jun 24, 2026

Using Motion Capture Technology in the Instrumented Timed Up and Go Test to Detect the Risk of Falling in Aged Adults
05:26

Using Motion Capture Technology in the Instrumented Timed Up and Go Test to Detect the Risk of Falling in Aged Adults

Published on: October 25, 2024

Using a Real-Time Locating System to Measure Walking Activity Associated with Wandering Behaviors Among Institutionalized Older Adults
04:13

Using a Real-Time Locating System to Measure Walking Activity Associated with Wandering Behaviors Among Institutionalized Older Adults

Published on: February 8, 2019

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

  • Combining drugs within the same therapeutic class or mixing psychotropic and cardiovascular drugs further elevates fall risk.
  • Intervention studies demonstrate that reducing or withdrawing fall-risk increasing drugs (FRIDs) effectively lowers the incidence of falls.

    • Impact:

    • Emphasizes the critical need for systematic medication review in geriatric fall prevention programs.
    • Identifies psychotropic and cardiovascular drugs as key targets for fall risk reduction interventions.
    • Suggests a knowledge gap regarding the potential of drug treatments to improve elderly mobility and decrease fall risk.