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12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Systemic lupus erythematosus in Egyptian children
Samia Salah1, Hala Mohamed Lotfy, Samar M Sabry
1Cairo University Hospital, Cairo, Egypt.
Rheumatology International
|March 21, 2009
Summary
This study characterizes systemic lupus erythematosus (SLE) in Egyptians, finding similarities to Middle Eastern populations but a lower female-to-male ratio. Early-onset SLE (<5 years) is rare and often presents with hematological issues.
Area of Science:
- Rheumatology
- Immunology
- Internal Medicine
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse clinical manifestations.
- Understanding population-specific characteristics of SLE is crucial for effective management and research.
- Previous studies have highlighted variations in SLE presentation across different ethnic and geographic groups.
Purpose of the Study:
- To investigate the clinical and laboratory characteristics of SLE in the Egyptian population.
- To compare these findings with those reported in other global populations, particularly in the Middle East.
- To identify unique features or trends in Egyptian SLE patients.
Main Methods:
- Retrospective analysis of 207 Egyptian patients diagnosed with SLE between 1990 and 2005.
- Collection and statistical analysis of clinical features and laboratory data.
- Comparison of patient demographics, disease onset, manifestations, and outcomes.
Main Results:
- The study included 151 females and 56 males (female to male ratio 2.7:1), with a mean age at presentation of 10 years.
- Common initial manifestations included musculoskeletal, constitutional, and mucocutaneous symptoms.
- During follow-up, nephritis (67%), hematological (44.9%), and neuropsychiatric (24.25%) manifestations were significant, with kidney involvement being the most common cause of death.
- Patients with disease onset ≤5 years (4.35% of cohort) showed a significantly higher prevalence of hematological affection (P=0.0005).
Conclusions:
- Egyptian SLE patients share some characteristics with other Middle Eastern populations but exhibit a lower female to male ratio.
- Early-onset SLE (<5 years) is uncommon but frequently presents with hematological involvement.
- Renal disease is a major complication and cause of mortality in this Egyptian SLE cohort.
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