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Updated: Jun 24, 2026
06:59
Quantification of Atherosclerosis in Mice
Published on: June 12, 2019
Molecular genetics of atherosclerosis
Himadri Roy1, Shalini Bhardwaj, Seppo Yla-Herttuala
1Department of Molecular Medicine and Biotechnology, A.I. Virtanen Institute, University of Kuopio, Kuopio, Finland. himadri.roy@uku.fi
Human Genetics
|March 21, 2009
Summary
Genetic factors significantly impact atherosclerosis risk. This review highlights key candidate genes and polymorphisms contributing to atherosclerotic vascular diseases, aiding in understanding disease susceptibility.
Area of Science:
- Cardiovascular Genetics
- Molecular Medicine
- Vascular Biology
Background:
- Atherosclerosis is a complex arterial disease influenced by genetic and environmental factors.
- Molecular genetics advances reveal significant genetic influences on atherosclerotic vascular disease susceptibility.
- Numerous candidate genes and polymorphisms linked to atherosclerosis have been identified.
Purpose of the Study:
- To review major candidate genes and genetic polymorphisms associated with human atherosclerotic vascular diseases.
- To synthesize current knowledge on genetic contributions to atherosclerosis.
- To provide an overview of key genetic factors influencing disease risk.
Main Methods:
- Literature review of candidate genes and genetic polymorphisms in atherosclerosis.
- Analysis of identified susceptibility loci and their association with disease.
- Focus on major genes and polymorphisms reported in recent research.
Main Results:
- Identification of several major candidate genes implicated in atherosclerosis.
- Association of specific genetic polymorphisms with increased susceptibility to atherosclerotic diseases.
- Growing number of identified genetic factors influencing disease development.
Conclusions:
- Genetic polymorphisms play a crucial role in determining individual susceptibility to atherosclerosis.
- Understanding these genetic factors is vital for comprehending the multifactorial nature of the disease.
- Further research into genetic determinants will advance personalized approaches to atherosclerosis prevention and treatment.
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