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Elastomeric enriched biodegradable polyurethane sponges for critical bone defects: a successful case study reducing donor site morbidity.

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Biodegradable poly(ester urethane) urea scaffolds for tissue engineering: Interaction with osteoblast-like MG-63 cells.

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Farnesol-modified biodegradable polyurethanes for cartilage tissue engineering.

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Related Experiment Video

Updated: Jun 24, 2026

Ultrathin Porated Elastic Hydrogels As a Biomimetic Basement Membrane for Dual Cell Culture
11:34

Ultrathin Porated Elastic Hydrogels As a Biomimetic Basement Membrane for Dual Cell Culture

Published on: December 26, 2017

Microporous biodegradable polyurethane membranes for tissue engineering.

Yuen Kee Tsui1, Sylwester Gogolewski

  • 1Department of Orthopaedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong, SAR.

Journal of Materials Science. Materials in Medicine
|March 21, 2009
PubMed
Summary
This summary is machine-generated.

Biodegradable polyurethane membranes with controlled pores were created using a modified phase-inversion technique. These microporous membranes show promise for skin wound healing and as an artificial periosteum.

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Last Updated: Jun 24, 2026

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Membrane Technology

Background:

  • Biodegradable polymers are crucial for tissue engineering and regenerative medicine.
  • Developing functional membranes with controlled porosity is essential for biomedical applications.

Purpose of the Study:

  • To develop microporous membranes from biodegradable polyurethane with controlled pore size and structure.
  • To optimize the phase-inversion technique for producing these membranes.
  • To evaluate the potential of these membranes for skin wound cover and as an artificial periosteum.

Main Methods:

  • Modified phase-inversion technique using biodegradable polyurethane.
  • Investigated parameters: solvent type, solvent-nonsolvent ratio, polymer concentration, solidification time, and layer thickness.
  • Evaluated polymer-N,N-dimethylformamide-water, polymer-N,N-dimethylacetamide-water, and polymer-dimethylsulfoxide-water systems.

Main Results:

  • The polymer-N,N-dimethylformamide-water system yielded the best results.
  • Optimal conditions: 5% (w/v) polymer concentration, 10% (v/v) nonsolvent, 23°C cast temperature, and 24-48h solidification time.
  • Resulting membranes exhibited interconnected pores, defined structure, good water permeability, and satisfactory mechanical properties for suturing.

Conclusions:

  • Optimized phase-inversion successfully produced microporous biodegradable polyurethane membranes.
  • These membranes possess characteristics suitable for skin wound dressings.
  • Potential application as an artificial periosteum in cartilage defect repair was demonstrated.