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Updated: Jun 24, 2026

A Micropatterning Assay for Measuring Cell Chirality
Published on: March 11, 2022
Rotation of organizer tissue contributes to left-right asymmetry
Cheng Cui1, Charles D Little, Brenda J Rongish
1Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.
Abstract:
Current hypotheses regarding vertebrate left-right asymmetry patterns are based on the presumption that genetic regulatory networks specify sidedness via extracellular morphogens and/or ciliary activity. We show empirical time-lapse evidence for an asymmetric rotation of epiblastic nodal tissue in avian embryos. This rotation spans the interval when initial symmetric expression of Shh and Fgf8 becomes asymmetrical with respect to the midline.
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