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Updated: Jun 24, 2026
Preterm EEG: A Multimodal Neurophysiological Protocol
Published on: February 18, 2012
Preterm birth prevention by 17 alpha-hydroxyprogesterone caproate vs. daily nursing surveillance
Charles Rittenberg1, Roger B Newman, Niki B Istwan
1Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC 29425, USA.
Objective:
To compare the incidence of spontaneous recurrent preterm delivery (SPTD) between women receiving 17 alpha-hydroxyprogesterone caproate (17P) and women receiving daily perinatal nursing surveillance (dPNS) with home uterine activity monitoring.
Study Design:
Women enrolled for dPNS or weekly nursing visits with 17P injection were eligible. Included were singletons with previous SPTD, without preterm labor (PTL), cerclage or vaginal bleeding and < 27 weeks at enrollment. 17P and dPNS patients were matched 1:1 by race, marital status, tobacco use and number of SPTDs. Primary study outcome was incidence of spontaneous PTD.
Results:
Data from 342 matched pairs were compared. Diagnosis of PTL (39.2% vs. 60.8%) and tocolytic use (12.9% vs. 49.7%) was decreased with 17P vs. dPNS (p < 0.001). The incidences of spontaneous PTD at < 32, 35 and 37 weeks were similar between the groups.
Conclusion:
There was no difference in recurrent SPTD between women treated with 17P and those receiving dPNS.
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