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Paraoxonasel phenotype distribution in Thais.

Sureerut Porntadavity1, Soontharee Tantrarongroj, Phanee Pidetcha

  • 1Department of Clinical Chemistry, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand. mtspy@mahidol.ac.th

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|March 24, 2009
PubMed
Summary

This study found that the Thai population exhibits a trimodal distribution of paraoxonase 1 (PON1) phenotypes, with a high prevalence of the BB phenotype. PON1 activity showed significant interindividual variability.

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Area of Science:

  • Biochemistry
  • Human Genetics
  • Population Health

Background:

  • Paraoxonase 1 (PON1) is an enzyme crucial for hydrolyzing organophosphates and protecting against oxidative stress.
  • Understanding PON1 activity and phenotype distribution is vital for assessing population-specific health risks and drug metabolism.

Purpose of the Study:

  • To characterize the paraoxonase 1 (PON1) enzyme activity.
  • To determine the phenotype distribution of PON1 in a healthy Thai population.

Main Methods:

  • A prospective descriptive study was conducted on 160 healthy Thai individuals (aged 20-74).
  • Paraoxonase and arylesterase activities were measured using a dual substrate method.
  • Phenotype distribution was analyzed based on the ssPON/ARE ratio.

Main Results:

  • Significant interindividual variability in PON1 activity was observed (up to 6.9-fold for paraoxonase, 4.6-fold for arylesterase).
  • A trimodal distribution of PON1 phenotypes (AA, AB, BB) was identified, with frequencies of 14.4%, 51.9%, and 33.7%, respectively.
  • The BB phenotype showed the highest frequency, and associations between sex, lipid parameters, and PON1 activity were noted.

Conclusions:

  • The Thai population displays a distinct trimodal distribution of PON1 phenotypes.
  • The BB phenotype is the most prevalent in this population.
  • Further research into sex-specific associations with PON1 activity and lipid profiles is warranted.