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Updated: Jun 24, 2026
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Large-Scale Multi-Omics Genome-Wide Association Studies (Mo-GWAS): Guidelines for Sample Preparation and Normalization
Published on: July 27, 2021
[Nutritional genomics: an approach to the genome-environment interaction]
Fiona Xacur-García1, Jorge I Castillo-Quan, Víctor M Hernández-Escalante
1Fundación Mexicana para la Salud, Capítulo Peninsular A.C. Mérida, Yucatán, México.
Revista Medica De Chile
|March 24, 2009
Summary
Nutritional genomics explores how diet interacts with our genes, influencing metabolism and disease risk. Understanding this gene-diet interaction offers personalized therapeutic and preventive health strategies.
Area of Science:
- Genomic Sciences
- Metabolic Research
Context:
- Investigates the complex interplay between dietary components and human genetic makeup.
- Encompasses nutrigenomics (nutrient effects on biological molecules) and nutrigenetics (genetic variation in diet-disease links).
Purpose:
- To elucidate the mechanisms driving gene-diet interactions.
- To explore the influence of diet on metabolism and disease susceptibility.
Summary:
- Nutritional genomics examines how diet affects metabolism and disease risk through gene-nutrient interactions.
- Mechanisms include transcription factor regulation, signaling pathway modulation, and epigenetic modifications like DNA methylation.
- Specific dietary elements, such as polyunsaturated fatty acids, can significantly alter gene expression and metabolic processes.
Impact:
- Potential for targeted therapies and preventive strategies for various conditions, including genetic disorders, metabolic diseases (dyslipidemia, diabetes), cancer, and age-related changes.
- Applications extend to mood, memory, pregnancy, and general population health maintenance.
- Enables personalized nutrition approaches for individuals with specific genetic predispositions or existing diseases.
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