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Updated: Jun 24, 2026

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition
Published on: February 9, 2024
Molecular recognition by contact angle: proof of concept with DNA hybridization
Paolo Bergese1, Giulio Oliviero, Italo Colombo
1Chemistry for Technologies Laboratory and INSTM, University of Brescia, Via Branze 38, 25123 Brescia, Italy. paolo.bergese@ing.unibs.it
Abstract:
A molecular recognition reaction supported by a solid-phase assay drives a specific change in the solid-solution interfacial tension. This prompts contact angle (CA) analysis, being a straightforward route to evaluate this property, to play the unedited role of label-free probe of the reaction. The concept is proven by the successful recognition of DNA hybridization and is further supported by the agreement between the results and the underpinning thermodynamics.
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