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Updated: Jun 24, 2026
Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
Incorporating time postinoculation into a dose-response model of Yersinia pestis in mice
Y Huang1, T A Bartrand, C N Haas
1Department of Civil, Architectural and Environmental Engineering, Drexel University, Philadelphia, PA 19104, USA. yh89@drexel.edu
Aims:
To develop a time-dependent dose-response model for describing the survival of animals exposed to Yersinia pestis.
Methods And Results:
Candidate time-dependent dose-response models were fitted to a survival data set for mice intraperitoneally exposed to graded doses of Y. pestis using the maximum likelihood estimation method. An exponential dose-response model with the model parameter modified by an inverse-power dependency of time postinoculation provided a statistically adequate fit to the experimental survival data. This modified model was verified by comparison with prior studies.
Conclusions:
The incorporated time dependency quantifies the expected temporal effect of in vivo bacteria growth in the dose-response relationship. The modified model describes the development of animal infectious response over time and represents observed responses accurately.
Significance And Impact Of The Study:
This is the first study to incorporate time in a dose-response model for Y. pestis infection. The outcome may be used for the improved understanding of in vivo bacterial dynamics, improved postexposure decision making or as a component to better assist epidemiological investigations.
