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Detection of 20-hydroxyeicosatetraenoic acid in rat urine
M L Schwartzman1, K Omata, F M Lin
1Department of Pharmacology, New York Medical College, Valhalla 10595.
Biochemical and Biophysical Research Communications
|October 15, 1991
Abstract:
20-Hydroxyeicosatetraenoic acid (20-HETE), an arachidonate metabolite of the cytochrome P450 omega hydroxylase, was detected in rat urine by gas chromatography-mass spectrometric techniques. The concentration of 20-HETE in urine from 7-week-old hypertensive and normotensive rats was 2.1 and 1.3 nM, respectively. This is the first demonstration of 20-HETE urinary excretion and thus calls attention to the possibility that 20-HETE participates in the regulation of renal function via its effect on vascular tone and ion transport processes.