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Changes in plasma lipoprotein metabolism in chicks in response to polychlorinated biphenyls (PCBs)
H Griffin1, D Windsor, J Brolakoglu
1AFRC Institute of Animal Physiology and Genetics Research, Roslin, Midlothian, U.K.
Biochemical Pharmacology
|September 12, 1991
Abstract:
The results of the present study strongly suggest that the hypertriglyceridaemia in chicks treated with Aroclor 1254 is a result of reduction in VLDL clearance rather than an increase in rate of VLDL secretion. The decrease in post-heparin LPL activity responsible for reduced VLDL clearance may be mediated by cytokines produced by chronic activation of the immune system.