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Updated: Jun 24, 2026
Laparoscopic Choledochal Cyst Excision and Roux-en-Y Choledochojejunostomy in Adults
Published on: February 28, 2025
Association of gastroschisis and choledochal cyst
Julia Serber1, Enno Stranzinger, James D Geiger
1Section of Pediatric Surgery, C S Mott Children's Hospital, University of Michigan Health System, Ann Arbor, MI 48109, USA.
Insights
Two infants with direct hyperbilirubinemia, initially thought to be due to gastroschisis and parenteral nutrition, were found to have choledochal cysts. This highlights the need to rule out anatomical causes of neonatal jaundice.
Area of Science:
- Neonatology
- Pediatric Surgery
- Gastroenterology
Background:
- Direct hyperbilirubinemia in neonates is often associated with gastroschisis and parenteral nutrition.
- Choledochal cysts are congenital dilations of the bile ducts.
Purpose of the Study:
- To report a novel association between gastroschisis, parenteral nutrition, and choledochal cysts in neonates.
- To emphasize the importance of considering anatomical abnormalities in neonatal direct hyperbilirubinemia.
Main Methods:
- Case report of two infants presenting with neonatal direct hyperbilirubinemia.
- Review of clinical presentation, diagnostic workup, and management.
Main Results:
- Both infants initially presumed to have hyperbilirubinemia secondary to gastroschisis and parenteral nutrition.
- Both infants were ultimately diagnosed with an associated choledochal cyst.
Conclusions:
- The association of choledochal cysts with gastroschisis and neonatal direct hyperbilirubinemia is novel.
- Anatomical causes, such as choledochal cysts, must be investigated in neonates with direct hyperbilirubinemia, even with confounding factors like gastroschisis.
Abstract:
Two infants are described who presented in the neonatal period with a direct hyperbilirubinemia. This was initially presumed to be because of the diagnosis of gastroschisis and the prolonged use of parenteral nutrition. However, both infants were eventually found to have an associated choledochal cyst. The cases are a novel association not previously reported and should heighten the awareness that anatomical causes of a direct hyperbilirubinemia need to be ruled out in all neonates.
