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Three job stress models/concepts and oxidative DNA damage in a sample of workers in Japan

Akiomi Inoue1, Norito Kawakami, Masao Ishizaki

  • 1Department of Mental Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. akiomi-tky@umin.ac.jp

Journal of Psychosomatic Research
|March 24, 2009
PubMed

Insights

Job stress may increase oxidative DNA damage, a risk factor for heart disease. Lower interactional justice in men and high job demands in women were linked to higher DNA damage markers.

Area of Science:

  • Occupational Health
  • Biomarkers
  • Cardiovascular Disease Etiology

Background:

  • Job stress models like the Job Demands-Control (DC) model, Effort-Reward Imbalance (ERI) model, and organizational justice are linked to coronary heart disease (CHD).
  • Oxidative DNA damage is an emerging risk factor for CHD, but its association with occupational stressors is not well-established.
  • Understanding the link between job stress and oxidative DNA damage may reveal mediating pathways for adverse health outcomes.

Purpose of the Study:

  • To investigate the association between job stress models (DC, ERI, organizational justice) and oxidative DNA damage.
  • To explore oxidative DNA damage as a potential mediator in the relationship between job stress and CHD.
  • To examine gender-specific associations between job stressors and oxidative DNA damage.

Main Methods:

  • Cross-sectional study of 217 manufacturing factory workers (166 male, 51 female) in Japan.
  • Mailed questionnaires assessed job stressors, demographics, occupation, and lifestyle factors.
  • Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) concentrations measured as a biomarker of oxidative DNA damage.

Main Results:

  • In male workers, lower interactional justice (a component of organizational justice) was significantly associated with higher urinary 8-OHdG levels.
  • No significant association was found between the DC model or ERI model and 8-OHdG in male subjects.
  • In female workers, a high job demands-to-control ratio was significantly and positively associated with elevated urinary 8-OHdG concentrations.

Conclusions:

  • Job stress, specifically lower interactional justice in men and high demands in women, may be linked to increased oxidative DNA damage.
  • These findings suggest that oxidative DNA damage could be a mechanism through which certain job stressors impact cardiovascular health.
  • Further research is warranted to confirm these associations and explore intervention strategies.
Abstract

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