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A framework for planning and critiquing medication compliance and persistence research using prospective study
Femida H Gwadry-Sridhar1, Elizabeth Manias, Ying Zhang
1Departments of Medicine and Physiology & Pharmacology, University of Western Ontario, London, Ontario, Canada. femida.gwadry-sridhar@lhsc.on.ca
Clinical Therapeutics
|March 24, 2009
Summary
Ensuring proper medication compliance and persistence is crucial for patient outcomes. This study introduces a framework to assess the quality of prospective studies on medication adherence, improving data interpretation.
Area of Science:
- Health Services Research
- Clinical Pharmacy
- Evidence-Based Medicine
Background:
- Medication compliance and persistence significantly influence clinical outcomes.
- Effective evidence-based therapy necessitates robust study designs for compliance and persistence outcomes.
Purpose of the Study:
- To outline designs of medication compliance/persistence studies.
- To offer guidance on appropriate analytical methods.
- To aid healthcare providers and payers in understanding adherence impact on health outcomes.
Main Methods:
- Systematic literature search of MEDLINE, CINAHL, EMBASE, and EBM Reviews (1978-2008).
- Inclusion of prospective medication compliance and persistence studies.
- Exclusion of retrospective designs and opinion-based articles.
Main Results:
- Development of a systematic framework including a prospective checklist and a quantitative quality assessment tool.
- Key checklist elements cover study components from title to conflict of interest disclosure.
- Examples provided to aid in evaluating study design, value, and quality.
Conclusions:
- The developed tools offer objective validation for prospective research rigor.
- Anticipation of uniform approaches in future research for clearer understanding of adherence impact.
- Facilitating a better comprehension of how compliance and persistence affect health outcomes.
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