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Kidney biopsy in systemic lupus erythematosus. II. Survival analyses according to biopsy results
J McLaughlin1, D D Gladman, M B Urowitz
1University of Toronto Rheumatic Disease Unit, Wellesley Hospital and Women's College Hospital, Ontario, Canada.
Abstract:
Renal biopsy specimens from 123 patients with systemic lupus erythematosus (SLE) seen between 1970 and 1984 were assessed according to the World Health Organization classification and according to the presence of proliferative, active, or chronic renal lesions. Survival analysis was used to study the determinants of mortality. Survival rates were higher for patients with minimal lesions, intermediate for patients with focal or diffuse proliferative nephritis, and low for patients with glomerular sclerosis. The presence of proliferative and chronic lesions was associated with a higher risk of dying. Renal biopsy results are helpful in predicting prognosis for all-cause mortality in patients with SLE.