Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...

Liver Regeneration

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A retrospective multicentre clinical study on management of isolated splenic vein thrombosis: risks and benefits of anticoagulation.

Langenbeck's archives of surgery·2024

Same author

Outcome of Surgical Fixation for Midfoot Charcot Neuroarthropathy - A Systematic Review.

Malaysian orthopaedic journal·2023

Same author

One-year follow-up of conservative management of appendicitis: results from a single centre during extended lockdown in the COVID-19 pandemic.

Annals of the Royal College of Surgeons of England·2022

Same author

Retrospective observational study of patient outcomes with local wound infusion vs epidural analgesia after open hepato-pancreato-biliary surgery.

BMC anesthesiology·2022

Same author

Fe-Mn doped powdered activated carbon pellet as ozone catalyst for cost-effective phenolic wastewater treatment: Mechanism studies and phenol by-products elimination.

Journal of hazardous materials·2021

Same author

Seeing the light: surgical circadian rhythm.

The British journal of surgery·2021

Search research articles

Related Experiment Video

Updated: Jun 24, 2026

A Mouse Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy Procedure Aided by Microscopy

A Mouse Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy Procedure Aided by Microscopy

Published on: January 19, 2024

Predicting liver failure following major hepatectomy.

G Garcea¹, S L Ong, G J Maddern

¹Department of Hepatobiliary and Upper Gastrointestinal Surgery, The Queen Elizabeth Hospital, Adelaide, SA 5011, Australia. gg43@le.ac.uk

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

|March 24, 2009

Summary

Pre-operative liver function tests are debated. This review examines evidence for quantifying functional liver remnant volume to assess surgical risk, finding no clear difference in outcomes between routine testing and clinical judgment alone.

More Related Videos

Extended 78% Hepatectomy in a Mouse Surgical Model

Extended 78% Hepatectomy in a Mouse Surgical Model

Published on: May 24, 2024

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure

Published on: August 14, 2017

Related Experiment Videos

Last Updated: Jun 24, 2026

A Mouse Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy Procedure Aided by Microscopy

A Mouse Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy Procedure Aided by Microscopy

Published on: January 19, 2024

Extended 78% Hepatectomy in a Mouse Surgical Model

Extended 78% Hepatectomy in a Mouse Surgical Model

Published on: May 24, 2024

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure

Published on: August 14, 2017

Area of Science:

Hepatology
Surgical Oncology
Medical Diagnostics

Background:

Pre-operative assessment of liver function is crucial for surgical risk stratification.
Current practices vary, with some centers using routine liver function tests and others relying solely on clinical judgment.
There is ongoing debate regarding the clinical utility of routine pre-operative liver dysfunction risk determination.

Purpose of the Study:

To review and present the evidence supporting the pre-operative quantification of functional liver remnant volume.
To evaluate the role of functional liver remnant volume measurement in predicting post-operative liver dysfunction.
To inform clinical practice regarding the optimal methods for assessing pre-operative liver reserve.

Main Methods:

Systematic review of published literature.
Analysis of studies comparing routine liver function testing versus clinical judgment alone.
Evaluation of data on mortality, morbidity, and liver failure rates.
Presentation of evidence for pre-operative quantification techniques for functional liver remnant volume.

Main Results:

Published data do not indicate significant differences in mortality, morbidity, or liver failure rates between centers using uniform pre-operative testing and those relying on clinical judgment.
Evidence for the pre-operative quantification of functional liver remnant volume is outlined.
The review synthesizes findings related to the predictive value of remnant liver volume measurements.

Conclusions:

The clinical usefulness of routine pre-operative liver dysfunction risk tests is questioned.
No definitive evidence supports a difference in major adverse outcomes based on the chosen pre-operative assessment strategy.
Further evaluation of pre-operative quantification of functional liver remnant volume is warranted to refine surgical risk assessment.