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Updated: Jun 24, 2026

In vitro Functional Characterization of Mouse Colorectal Afferent Endings
Published on: January 21, 2015
[Intestinal motility disorders and visceral hypersensitivity in irritable bowel syndrome]
1Explorations Fonctionnelles Digestives, CHU Pontchaillou, rue H. Le Guillou, 35033 Rennes cedex, France. alain.ropert@chu-rennes.fr
Abstract:
The pathophysiology of irritable bowel syndrome is complex, secondary to a dysregulation of the visceral neuromuscular system. Motor disorders and digestive hypersensitivity have been studied most: phasic and tonic abnormalities and visceral hypersensitivity associated with different types of receptors have been identified in patients with irritable bowel syndrome. For other patients, the combination of these disorders can explain abnormal physiological responses. Some records of various explorations are correlated with patient symptoms, such as pain, bloating, or bowel movement disorders. These sensorimotor disorders, probably not limited to the gut, are reviewed in this article.
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