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The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
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A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
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[Brain-gut axis dysfunction].

B Bonaz1, J-M Sabate

  • 1Clinique Universitaire d'Hépato-Gastroentérologie et Stress et Interactions neuro-Digestives, Grenoble Institut des Neurosciences (GIN, Centre de Recherche INSERM U836-UJF-CEA-CHU), CHU de Grenoble, BP217, 38043 Grenoble cedex 09, France. BBonaz@chu-grenoble.fr

Gastroenterologie Clinique Et Biologique
|March 24, 2009
PubMed
Summary
This summary is machine-generated.

The brain-gut axis, crucial for irritable bowel syndrome (IBS), shows dysfunction in IBS patients. This dysfunction involves visceral hypersensitivity and autonomic nervous system disturbances, impacting treatment strategies.

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Area of Science:

  • Neurogastroenterology
  • Central Nervous System Disorders
  • Digestive System Physiology

Context:

  • Irritable bowel syndrome (IBS) is increasingly understood to involve complex interactions between the brain and the gut.
  • Dysfunction in the brain-gut axis is a key feature in IBS pathophysiology.
  • Visceral hypersensitivity, a hallmark of IBS, is linked to brain-gut axis abnormalities.

Purpose:

  • To explore the role of brain-gut axis dysfunction in irritable bowel syndrome (IBS).
  • To investigate the origins and implications of visceral hypersensitivity in IBS.
  • To highlight the impact of neuroscientific advancements on understanding IBS.

Summary:

  • The brain-gut axis exhibits bidirectional communication, and its dysfunction is implicated in IBS.
  • Visceral hypersensitivity in IBS can stem from peripheral or central mechanisms, potentially involving inflammation or altered nociceptive processing.
  • Stress and autonomic nervous system disturbances are associated with IBS due to brain-gut axis dysfunction.
  • Neuroimaging techniques have advanced the understanding of IBS physiopathology.

Impact:

  • Improved comprehension of IBS pathophysiology through neuroscientific insights.
  • Potential for novel therapeutic strategies targeting the brain-gut axis in IBS.
  • Integration of pharmacological and psychobehavioral therapies for IBS management.