Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
Cardiac Action Potential01:30

Cardiac Action Potential

Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Phosphorylation01:02

Phosphorylation

The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
Phosphorylation01:02

Phosphorylation

The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
Roles of Electrolytes: Calcium and Phosphate01:27

Roles of Electrolytes: Calcium and Phosphate

Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily regulated...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lung Carcinoids-Time to Change Practices.

Current oncology (Toronto, Ont.)·2026
Same author

Metabolic Outcomes in Bariatric/Metabolic Surgery Individuals: Impact of Metabolic Health Definition, Type of Surgery, and Follow-Up Duration-An Observational, Retrospective Study.

Metabolites·2026
Same author

Should Children Drink Water with Very Low Mineral Content? Implications of the Global Expansion of Water Filtration Systems and Relevance of Consumption of Water with Higher Mineralization Levels.

Nutrients·2026
Same author

Advantages and disadvantages of online psychotherapy and decisions to use it in the era of the COVID-19 pandemic - analysis of mediation variables.

Frontiers in psychiatry·2025
Same author

MOBAK 3-4: Construct Validity and Score Reliability in an 8-10-Year-Old Portuguese Sample Within the Cascais Municipality.

Perceptual and motor skills·2025
Same author

Multi-center Assessment of DLL3 Expression by Immunohistochemistry in Medullary Thyroid Carcinoma.

Endocrine pathology·2025
Same journal

Clinical outcomes of intravascular imaging-guided versus angiography-guided drug-coated balloon angioplasty for de novo coronary lesions.

International journal of cardiology·2026
Same journal

Hypertension management in obstructive hypertrophic cardiomyopathy patients treated with cardiac myosin inhibitors - real world data.

International journal of cardiology·2026
Same journal

Fully quantitative CMR rest perfusion reveals myocardial perfusion abnormality in Kawasaki disease: Association with left ventricular Remodeling.

International journal of cardiology·2026
Same journal

Predicted adherence and ischaemic stroke risk in atrial fibrillation patients initiating oral anticoagulation: A cohort study of the medication adherence score.

International journal of cardiology·2026
Same journal

Severe tricuspid regurgitation is a congestion-driven cardiorenal disease: A longitudinal study defining a right heart failure phenotype.

International journal of cardiology·2026
Same journal

Applicability of ischemic heart disease clinical practice guidelines in low- and middle-income countries.

International journal of cardiology·2026
See all related articles

Related Experiment Video

Updated: Jun 24, 2026

Assessment of Cardiac Function and Energetics in Isolated Mouse Hearts Using 31P NMR Spectroscopy
11:38

Assessment of Cardiac Function and Energetics in Isolated Mouse Hearts Using 31P NMR Spectroscopy

Published on: August 31, 2010

Let's think in alkaline phosphatase at heart function.

Maria João Martins, Isabel Azevedo

    International Journal of Cardiology
    |March 24, 2009
    PubMed
    Summary
    This summary is machine-generated.

    Elevated alkaline phosphatase in the blood is linked to peripheral arterial disease. Researchers found heart alkaline phosphatase may regulate heart function and serve as a therapeutic target.

    More Related Videos

    Colorimetric Analysis of Alkaline Phosphatase Activity in S. aureus Biofilm
    04:59

    Colorimetric Analysis of Alkaline Phosphatase Activity in S. aureus Biofilm

    Published on: April 12, 2019

    Direct Detection of Isolevuglandins in Tissues Using a D11 scFv-Alkaline Phosphatase Fusion Protein and Immunofluorescence
    06:33

    Direct Detection of Isolevuglandins in Tissues Using a D11 scFv-Alkaline Phosphatase Fusion Protein and Immunofluorescence

    Published on: July 5, 2021

    Related Experiment Videos

    Last Updated: Jun 24, 2026

    Assessment of Cardiac Function and Energetics in Isolated Mouse Hearts Using 31P NMR Spectroscopy
    11:38

    Assessment of Cardiac Function and Energetics in Isolated Mouse Hearts Using 31P NMR Spectroscopy

    Published on: August 31, 2010

    Colorimetric Analysis of Alkaline Phosphatase Activity in S. aureus Biofilm
    04:59

    Colorimetric Analysis of Alkaline Phosphatase Activity in S. aureus Biofilm

    Published on: April 12, 2019

    Direct Detection of Isolevuglandins in Tissues Using a D11 scFv-Alkaline Phosphatase Fusion Protein and Immunofluorescence
    06:33

    Direct Detection of Isolevuglandins in Tissues Using a D11 scFv-Alkaline Phosphatase Fusion Protein and Immunofluorescence

    Published on: July 5, 2021

    Area of Science:

    • Biochemistry
    • Cardiology
    • Molecular Biology

    Background:

    • A prior study linked elevated serum alkaline phosphatase to peripheral arterial disease, a cardiovascular risk factor.
    • This research confirmed the presence of alkaline phosphatase within rat heart tissue, specifically in the sarcoplasmic reticulum of cardiomyocytes.
    • Evidence suggests that drugs affecting cardiac function also interact with cardiac alkaline phosphatase activity.

    Discussion:

    • Alkaline phosphatase is localized within the heart, suggesting a potential role in cardiac physiology.
    • The enzyme's activity is modulated by cardiac-acting drugs, indicating a functional interaction.
    • These findings support the hypothesis that alkaline phosphatase acts locally within the heart.

    Key Insights:

    • Alkaline phosphatase is present in rat heart sarcoplasmic reticulum.
    • Cardiac alkaline phosphatase activity is influenced by drugs with cardiac effects.
    • Alkaline phosphatase is proposed as a local regulator of heart function.

    Outlook:

    • Investigate the precise role of cardiac alkaline phosphatase in cardiomyocyte function.
    • Explore alkaline phosphatase as a potential therapeutic target for cardiovascular diseases.
    • Further research into drug interactions with cardiac alkaline phosphatase is warranted.