DISC1 partners with GSK3beta in neurogenesis
1Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. gming1@jhmi.edu
Cell
|March 24, 2009
Abstract:
The protein DISC1, encoded by a gene implicated in schizophrenia susceptibility, regulates the development of postmitotic neurons. Mao et al. (2009) now report that DISC1 also regulates the proliferation of embryonic and adult neural progenitor cells through the GSK3beta/beta-catenin pathway, providing new insights into how susceptibility genes may contribute to the etiology of psychiatric disorders.
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